发明名称 |
PECTIC SUBSTANCE AS A GROWTH FACTOR STABILIZER |
摘要 |
Pectic substance from Aloe Vera and other sources is used as a stabilizer and a delivery vehicle for pectin/heparin-binding proteins, such as pectin/heparin binding growth factors. Aloe pectin, a naturally occurring LM (low methoxyl) pectin, binds to pectin/heparin-binding growth factors, i.e., bFGF, aFGF, and KGF of fibroblast growth factor (FGF) family and TGF-beta1 of transforming growth factor-beta (TGF-beta) family. Commercial LM or HM (high methoxyl) citrus pectins tested did not exhibit any binding activity with bFGF. A weak binding to bFGF was observed with a de-esterified pectin (polygalacturonic acid) prepared from citrus. The binding protected the growth factor from protease digestion. The calcium gel beads prepared with Aloe pectin also bound to these pectin/heparin-binding growth factors. The growth factor could also be encapsulated in the pectin calcium gel and Aloe pectin sodium gel. Pectin/heparin-binding growth factor stabilized by pectin is used for wound healing. A pectin-containing matrix is used for the isolation of a pectin/heparin-binding protein. |
申请公布号 |
EP1100820(A1) |
申请公布日期 |
2001.05.23 |
申请号 |
EP19990923246 |
申请日期 |
1999.05.20 |
申请人 |
CARRINGTON LABORATORIES, INC. |
发明人 |
NI, YAWEI;YATES, KENNETH, M. |
分类号 |
A61K9/50;A61K36/886;A61K38/00;A61K38/18;A61K38/22;A61K47/00;A61K47/02;A61K47/04;A61K47/30;A61K47/32;A61K47/36;A61K47/38;C07K14/475;C07K14/50;C08B37/00;C08B37/06;(IPC1-7):C07K14/47;A61K38/17 |
主分类号 |
A61K9/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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