ANTHELMINTIC FLAVONES FROM STRUTHIOLA ARGENTA

摘要

Bioassay-guided isolation of three anthelmintic flavones 1-3, including a new flavone, 5,6,2',5',6'-pentamethoxy-3',4'-methylenedioxyflavone 2 from the methanol extract of Struthiola argenta (Thymelaeaceae). The two major flavones produced by this plant were also isolated and identified as yuankanin (4) and amentoflavone (5). A number of flavones related to the compounds isolated from S. argenta were acquired and tested to ascertain structure activity relationships. The isolation, structure, anthelmintic activity and structure activity relationships of flavones are described. The new compound 2 exhibited the most potent in vitro activity with 90% inhibition of larval motility at 3.1 µg/mL and compound 15 showed modest in vivo activity.