METHOD OF SELECTIVELY INHIBITING PKCIOTA

摘要

PKCiota inhibitor1 H-imidazole-4-carboxamide, 5-amino-1 -[2,3-dihydroxy-4-[(phosphonooxy) methyl] cyclopentyl] -,[1 R-(1a, 2ß, 3 ß, 4 a)], (ICA-1 ), targets a unique sequence (amino acid residues 469-475) in the catalytic domain of PKCiota and inhibits PKCiota activity. The data shows suprising and unexpected ability of ICA-1 to slectively inhibit the proliferation of cells that overexpress PKCiota.