METHOD OF PRODUCING CHITOSAN-BASED FILMS USING ION CROSS-LINKING REAGENTS

摘要

FIELD: biotechnology.SUBSTANCE: invention relates to processing polymers and biomedicine, in particular to development of chitosan-based insoluble but swellable materials with low toxicity and controlled release of drug compounds. For making films chitosan is dissolved in acetic acid, then 1.0-5.0 % solution of chitosan is added with ion cross-linking agent potassium pyrophosphate and/or sodium tripolyphosphate. Ionic cross-linking reagents with concentration of 1.0-2.5% are added to chitosan solution at the stage of producing molding solution at room temperature or with concentration of 3.0-5.0 % at temperature 60 °C and molar ratio of ionic compound-amines of chitosan equal to 0.029-0.121 mol/mol. Film can also contain myramistin in amount of 0.5 % of the weight of chitosan.EFFECT: this method allows to produce insoluble in water, but highly swellable chitosan films, ensuring prolonged therapeutic effect when added with biologically active compounds.1 cl, 2 dwg, 9 ex