PROTECTION AGAINST AMINOGLYCOSIDE-INDUCED NEPHROTOXICITY

摘要

The in vivo use of compounds which prevent the generation of, effectively scavenge, or detoxify a reactive oxygen metabolite that mediates a toxic effect of an aminoglycoside. The compounds of the invention can be used to prevent or reduce aminoglycoside-induced renal damage, and include but are not limited to free radical scavengers, iron chelators, oxidizable compounds, enzymes which metabolize reactive oxygen metabolites or their precursors, and biosynthetic precursors thereof.