发明名称 |
UNDERCARBOXYLATED/UNCARBOXYLATED OSTEOCALCIN INCREASES BETA-CELL PROLIFERATION, INSULIN SECRETION, INSULIN SENSITIVITY, GLUCOSE TOLERANCE AND DECREASES FAT MASS |
摘要 |
The present invention relates to methods and compositions for treating and diagnosing disorders related to energy metabolism and the OST-PTP signaling pathway involving gamma-carboxylase, osteocalcin and adiponectin. Such disorders include, but are not limited to, metabolic syndrome, glucose intolerance, diabetes types 1 and 2, atherosclerosis and obesity. |
申请公布号 |
WO2008033518(A2) |
申请公布日期 |
2008.03.20 |
申请号 |
WO2007US20029 |
申请日期 |
2007.09.13 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;KARSENTY, GERARD;DUCY, PATRICIA, F. |
发明人 |
KARSENTY, GERARD;DUCY, PATRICIA, F. |
分类号 |
A61K38/17 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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