摘要 |
Heterocyclic-substituted tricyclics of the formula or a pharmaceutically acceptable salt or solvate of said compound, isomer or racemic mixture wherein <img id="custom-character-00001" he="2.79mm" wi="7.37mm" file="US20080090830A1-20080417-P00001.TIF" img-content="character" img-format="tif"/> represents an optional double bonds the dotted line is optionally a bond or no bonds resulting in a double bond or a single bond, as permitted by the valency requirement and wherein E, A, G M, Het, B, X, R<SUP>3</SUP>, R<SUP>10</SUP>, R<SUP>11</SUP>, R<SUP>32 </SUP>and R<SUP>33 </SUP>are herein defined and the remaining substituents are as defined in the specification, are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failures and cancer by administering said compounds. Combination therapy with other cardiovascular agents is also claimed.
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