NOVEL CRYSTAL FORMS OF PYRROLYLHEPTANOIC ACID DERIVATIVES

摘要

The present invention provides novel crystalline forms D1 and D2 of [R-(R *,R* )]-2-(4- fluorophenyl)-.beta.,.delta.-dihydroxy-5-(l-methylethyl)-3-phe nyl-4-[(phenylamino)carbonyl]-1H- pyrrole- 1-heptanoic acid hemicalcium salt , and hydrates thereof. The crystalline forms D1 and D2 have X-ray powder di ffraction peaks described in Figs. 1 and 3, respectively. Further, the prese nt invention provides processes for preparing the crystalline forms and phar maceutical compositions comprising the crystalline forms. The crystalline fo rms can be produced on a commercial scale and exhibit excellent stability.