Pharmaceutical compounds for use in the therapy of <i>Clostridium difficile </i>infection

摘要

The invention relates to a compound described by a general formula (1), wherein each X independently can be OPO32−, OPSO22− or OSO3−; R1 comprises a solubility function such as a polyethylene glycol moiety and each X independently can be OPO32−, OPSO22−, − or OSO3−; and Z is an alkyl chain comprising 1 to 3 carbon and/or hetero atoms. The invention further relates to polysulfate derivatives or mixed polyphosphate/sulphate derivatives of six-membered cyclic polyols for use in the therapy of infection by Clostridium difficile.

主权项

1. A method for treating a C. difficile infection, comprising administering to a subject a composition comprising a compound described by general formula (16a) or (16b):wherein
a) X2 is OSO3−, and X1, X3, X4, X5 and X6 are each independently selected from OPO32−, OPSO22− or OSO3−; b) X1, X3 and X5 are OPO32− and X2, X4 and X6 are OSO3− c) X1, X3 and X5 are OSO3− and X2, X4 and X6 are OPO32− d) X4, X5 and X6 are OSO3− and X1, X2 and X3 are OPO32−, e) X4, X5 and X6 are OPO32− and X1, X2 and X3 are OSO3− or f) X2 and X5 are OPO32− and X1, X3, X4, and X6 are OSO3−, g) X2 and X5 are OSO3− and X1, X3, X4, and X6 are OPO32−, h) X2 and X3 are OPO32− and X1, X4, X5, and X6 are OSO3−, or i) X2 and X3 are OSO3− and X1, X4, X5, and X6 are OPO32−.