| 摘要 |
FIELD: organic chemistry, medicine, oncology. SUBSTANCE: invention relates to novel derivatives of indole of the formula (I): where R1 means hydrogen, halogen atom, CN; R2 and R3 are similar or different and mean hydrogen atom, C1-C4-alkyl, halogen atom; R4 means hydrogen atom, C1-C4-alkyl; means cyanophenyl group, aminosulfonylphenyl group, aminopyridyl group, aminopyrimidyl group, halogenpyridyl group or cyanothiophenyl group under condition that when all R1, R2, R3 mean hydrogen atom, when both R2 and R3 represent hydrogen atom or when ring represents aminosulfonylphenyl group and both R1 and R2 represent halogen atoms are excluded; and, except for, when ring represents cyanophenyl group, 2-amino-5-pyridyl group or 2-halogen-5-pyridyl group and R1 represents cyano-group or halogen group then at least one of R2 and R3 must not be hydrogen atom. Compounds of the formula (I) elicit an antiangiogenic effect and can be used as antitumor agents being especially against malignant tumors of pancreas, colon intestine, stomach, breast gland, prostate, lung, ovaries and other organs. EFFECT: valuable antitumor properties of compounds. 27 cl, 2 sch, 6 tbl, 10 ex |
