| 摘要 |
<p>NEW MATERIAL:A compound shown by formula I [R<1> is H or 1-4C alkyl; Xb and Yb are H or OH; Z is amino, mono- or di-(1-4C alkyl)amino, etc.]. EXAMPLE:(3aR,4R,12aR,12bS)4-amino-2,3,3a,4,5-12,12a,12b-octahydro-6- hydroxyindolo[3,2,1-ij]benz[de]quinolin-11(1H)one. USE:An antiarrhythmic agent. PREPARATION:An indole compound shown by formula II (R<2> is carboxyl- protecting group; Xa and Ya are protected OH) is reacted with an optically active compound shown by formula III to give a compound shown by formula IV, which is then heated to give a compound shown by formula V. Further this compound is isomerized, the protecting group is removed to give a compound shown by formula V, which is converted into an azide, heated and then reacted with a compound shown by formula R<3>OH (R<3> is 1-4C alkyl, etc.) to give a compound shown by formula VII. Optionally the protecting group is removed to give a compound shown by formula I.</p> |
