发明名称 |
Preparation for transdermal drug administration. |
摘要 |
<p>A preparation for transdermal drug administration comprising a flexible backing layer and a pressure-sensitive adhesive layer containing a local anesthetic in a proportion of 40-65 weight%. Since the ratio of the amount of the undissolved local anesthetic (Ac) to that of the dissolved local anesthetic (As), Ac/As, in the pressure-sensitive adhesive layer is determined to be in the range of 0.1-1.8, the preparation for transdermal drug administration of the present invention is superior in self-adhesiveness and leaves no adhesive material upon removal from the skin. In addition, burst-like release of the undissolved drug from the pressure-sensitive adhesive layer immediately after application to the skin permits rapid appearance of the anesthetic effect, which enables wide clinical application of the preparations of the present invention.</p> |
申请公布号 |
EP0488137(A2) |
申请公布日期 |
1992.06.03 |
申请号 |
EP19910120100 |
申请日期 |
1991.11.26 |
申请人 |
NITTO DENKO CORPORATION;LEDERLE (JAPAN), LTD. |
发明人 |
MASAKI, SUNAMI;KOJI, MARUYAMA;MITSUHIKO, HORI;SHOICHI, TOKUDA;KENICHIRO, SAITO;IKUO, KISHI |
分类号 |
A61K9/70;A61K31/165;A61K31/245;A61K31/46;A61K31/47;A61K45/00;A61P23/02;A61P25/02;A61P25/04 |
主分类号 |
A61K9/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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