| 摘要 |
Provided are novel vectors and viral vectors capable of expressing genes or exogenous nucleic acid sequences in a target cell of interest, such as T cells, bone marrow cells, epithelial cells, liver cells and the like. The nucleic acid components of the vectors may include one or more native promoter/enhancer regions having modified sequence segments, one or more non--native promoter/enhancer or non-native promoter's gene or gene segment, and a nativ e viral terminator or processing signal or segment thereof (see Figure 8). The viral vectors comprise a virus or viral portion having on the surfaces or envelopes adsorption components, one for a packaging cell line and the other for delivery to a target cell. Packaging cell lines for proprogating the vectors and viral vectors are also provided, as are novel processes for propagating any of the disclosed vectors or viral vectors.
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