DERIVATIVES OF 5-ARYL-3-(8-AZABICYCLO(3.2.1)OCT-3-YL)-1,3,4-OXADIAZOL-2(3H)-ON AS LIGANDS OF 5-HT4 RECEPTORS

摘要

The compounds have the general formula where R1 means alkyl or cycloalkylmetyl group, X1 is hydrogen or halogen atom, or alkoxygroup, or optionally OR1 and X1 together mean a group with the formula -OCH20-, -O(CH2)2-, -C(CH2)3-, -O(CH2)20- or -C(CH2)30-, X2 means hydrogen atom or aminogroup, X3 is hydrogen or halogen atom and R2 means hydrogen atom, alkyl group, phenylalkyl group or a group with the general formula -(CH2)nCO-Z where n means an integer from 1 to 6 and Z means 1-piperidyl group. The invention also relates to therapeutical application of the above compounds. 7 claims