| 摘要 |
[Problems] Conventional cancer vaccines activate only killer T cells, or killer T cells and helper T cells. Thus, no practical cancer vaccine preparation having an obvious capacity to activate antigen presenting cells simultaneously with them has been accomplished. [Solution Means] A preparation combining a complex of a cancer antigen and a hydrophobized polysaccharide with an agent, e.g., an extract fromhemolytic streptococcus, which binds to a Toll-like receptor to stimulate the antigen presenting cells activates all of the antigen presenting cells, the killer T cells and the helper T cells which are major immune cells when antigen specific immunity against cancer cells is induced and activated, and exerts a potent vaccinal effect. A vaccine preparation of the present invention induces immune responses to the cancer antigen, in particular, has effects of activation and induction of cytotoxic T cells and helper T cells, and thus, can be used as a therapeutic or preventive vaccine for cancer therapy.
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