| 摘要 |
The invention relates to a combination therapy for cancer treatment. In particular, the invention relates to a method for the treatment of cancer in a warm-blooded animal such as a human, which comprises administering to the animal an effective amount of a compound of Formula (I) refer to Formula I on page 43 of the specification wherein: X represents at any available ring position -CONH-, -SO2NH-, -O-, -CH2-, -NHCO- or -NHSO2-; R represents a lower C1-6 alkyl optionally substituted with one or more groups including hydroxyl, amino and N-oxides therefrom or dialkylamino and N-oxides therefrom; Y represents at any available ring position -N-aziridinyl, -N(CH2CH2W)2 or -N(CH2CHMeW)2, where each W is independently selected from halogen or -OSO2Me; Z represents at any available ring position -NO2, -halogen, -CN, -CF3 or -SO2Me; or a pharmaceutically acceptable salt or derivative thereof, before, after or simultaneously with an effective amount of docetaxel. |
