发明名称 |
Novel betullnic acid derivatives A-ring-condensed to a heterocyclic group |
摘要 |
The invention relates to novel betulinic acid derivatives of formula (I), wherein R is C(═CH2)CH3 or CH(CH3)2; R2 together with the adjacent carbonyl group forms a carboxylic acid, carboxylic acid ester or amide or substituted amide; R3 or R4 are hydrogen or aryl with the proviso that both are not independently hydrogen or alkyl or R3 and R4 are combined together to form an aryl ring optionally substituted with a group X, wherein X is selected from halogen, alkyl, cyano, nitro, alkoxy, amino or substituted amine; Y is N or O; and R1 is zero when Y is O, and R1 is hydrogen, alkyl or aryl alkyl when Y is N, useful for inhibition of tumor cancer cells. |
申请公布号 |
ZA200706393(B) |
申请公布日期 |
2009.11.25 |
申请号 |
ZA20070006393 |
申请日期 |
2007.08.01 |
申请人 |
DABUR PHARMA LIMITED |
发明人 |
MUKHERJEE, RAMA;SIDDIQUI, MOHAMMAD JAMSHED AHMED;SINGH, ANU T.;SINGH, MANOJ KUMAR;JAJOO, HEMANT KUMAR;KUMAR, VIVEK;AGARWAL, SHIV KUMAR;SRIVASTAVA, SANJAY KUMAR;JAGGI, MANU;VARDHAN, ANAND;RAJENDRAN, PRAVEEN;BURMAN, ANAND C.;RANI, NIDHI |
分类号 |
A61K;A61P;C07J |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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