发明名称 |
Use of NK-1 receptor antagonists in pruritus |
摘要 |
The invention relates to methods for treating pruritus with NK-1 receptor antagonists such as serlopitant. The invention further relates to pharmaceutical compositions comprising NK-1 receptor antagonists such as serlopitant. In addition, the invention encompasses treatment of a pruritus-associated condition with serlopitant and an additional antipruritic agent, and the use of serlopitant as a sleep aid, optionally in combination with an additional sleep-aiding agent. |
申请公布号 |
US9474741(B2) |
申请公布日期 |
2016.10.25 |
申请号 |
US201615175358 |
申请日期 |
2016.06.07 |
申请人 |
MENLO THERAPEUTICS INC. |
发明人 |
Zhang Xiaoming;Schnipper Edward F.;Perlman Andrew J.;Larrick James W. |
分类号 |
A61K31/4035;A61K45/06;A61K9/00;A61K9/20;A61K9/48 |
主分类号 |
A61K31/4035 |
代理机构 |
The Marbury Law Group, PLLC |
代理人 |
The Marbury Law Group, PLLC |
主权项 |
1. A method of treating pruritus associated with a liver disease, comprising administering a therapeutically effective amount of 3-[(3aR,4R,5S,7aS)-5-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-4-(4-fluorophenyl)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]cyclopent-2-en-1-one (serlopitant) or a pharmaceutically acceptable salt, solvate or polymorph thereof to a patient in need of treatment. |
地址 |
Menlo Park CA US |