CLATHRATE COMPLEX OF CYCLODEXTRIN OR ARABINOGALACTAN WITH 9-PHENYL-SYM-OCTAHYDROSELENOXANTHENE, METHOD FOR PREPARING THE SAME (VARIANTS), PHARMACEUTICAL COMPOSITION AND MEDICAMENT

摘要

The invention relates to novel clathrate complexes of cyclodextrin or arabinogalactan with 9-phenyl-sym-octahydroselenoxanthene, in a crystalline form. The clathrate complex may be in the crystalline form, in the form of nano-particles with a size of less than 100 nm. In the clathrate complex, cyclodextrin is selected from α-, β-, γ- or hydroxypropyl-β-cyclodextrin. The proposed clathrate complexes make it possible to increase the solubility of the active compound in water, to improve the bioaccessibility, to reduce the dosage of the drug and, consequently, to reduce the toxic effect of 9-phenyl-sym-octahydroselenoxanthene. The complexes exhibit cyto-radio-protective activity. The invention also relates to a liquid-phase and solid-phase method for producing clathrate complexes, and also to pharmaceutical compositions and drugs on the basis thereof.