发明名称 |
Method of detecting prions in a sample and transgenic animal used for same |
摘要 |
Prions are protein based infectious material that cause of variety of diseases such as Scrapie, bovine spongiform encephalopathy (also known as "Mad Cow" disease), Creutzfeldt Jakob Disease, Kuru, and fatal familial insomnia. The invention is directed to artificial prion genes that are made up of elements of the prion genes of a host and test species. When these artificial prion genes are inserted into a transgenic mouse, the resultant mouse becomes susceptible to infection with prions that infect the test species but do not normally infect mice. The transgenic animals are useful for testing for the presence of prions in a sample. |
申请公布号 |
AU2284195(A) |
申请公布日期 |
1995.12.05 |
申请号 |
AU19950022841 |
申请日期 |
1995.04.10 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
STANLEY B PRUSINER;MICHAEL R SCOTT;GLENN TELLING |
分类号 |
A01K67/027;A61K49/00;C07K14/47;C12N15/09;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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