Methods and compositions for treating fungal infections in mammals

摘要

Methods of treating fungal infections are disclosed. The methods comprise administering a chitin synthesis inhibitor to a mammal in a continuous fashion so that at least a minimum effective concentration is maintained in the mammal's plasma or in a target organ. In a preferred embodiment, the administration is by continuous intravenous infusion and the fungal infection is due to Candida albicans. In another preferred embodiment, the administration is by a sustained release formulation and the fungal infection is due to Candida albicans.