发明名称 |
1-BENZENESULFONYL PYRROLIDINE DERIVATIVES AS BRADYKININ RECEPTOR ANTAGONISTS |
摘要 |
This invention relates to compounds selected from the group of compounds of formula (I), where X is halogen, R1 is H or a C1-C3 alkyl, R2 is H or OH and R3 is represented by (a), (b), (c) or (d), in which A represents a single bond or a group -CO-(CH2)p-NH-, R4 represents H or -C(=NR5)NHR'5, R5 and R'5 each represent H or a C1-C6 alkyl group, R6 represents H or a C1-C3 alkyl group, m is 0, 1 or 2; n is 2, 3 or 4; p is 1, 2 or 3; plus their addition salts. The invention likewise relates to the method for their preparation and their therapeutic applications.
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申请公布号 |
WO9724349(A1) |
申请公布日期 |
1997.07.10 |
申请号 |
WO1996FR02066 |
申请日期 |
1996.12.23 |
申请人 |
FOURNIER INDUSTRIE ET SANTE;DODEY, PIERRE;BONDOUX, MICHEL;HOUZIAUX, PATRICK;BARTH, MARTINE;OU, KHAN |
发明人 |
DODEY, PIERRE;BONDOUX, MICHEL;HOUZIAUX, PATRICK;BARTH, MARTINE;OU, KHAN |
分类号 |
A61K31/00;A61K31/47;A61K31/4709;A61K31/495;A61K31/4965;A61K31/497;A61P29/00;A61P43/00;C07D401/12;C07D401/14;(IPC1-7):C07D401/12 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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