| 摘要 |
FIELD: medicine, pharmacy. SUBSTANCE: lyophilizate has buffer, alanine and mannitol at molar ratio alanine : mannitol = 1:(0.1-1). Enzyme urate oxidase, hormone hGH, interleukin-12 can be used as protein and phosphate buffer as a buffer. Alanine can be in crystalline form and mannitol - in an amorphous one. Protein containing in the composition retains stability at the room temperature. Water content in lyophilizate is compatible with protein activity retention. Invention can be used for making protein-containing preparations. EFFECT: improved quality and properties of the composition. 8 cl, 5 dwg, 5 tbl, 9 ex |
