Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof

摘要

A compound of the following structure: wherein R<1 >is H, an alkyl group, an aryl group, an alkenyl group, an alkynyl group, or a halogen atom; R<2 >is H, an alkyl group, an aryl group, a benzyl group, a trityl group, -SiRRR, CH2OR, or COR; R, Rand Rare independently an alkyl group or an aryl group; Ris an alkyl group, an aryl group, an alkoxylalkyl group, -RSiRRRor a benzyl group, wherein Ris an alkylene group; Ris an alkyl group, an allyl group, a benzyl group, an aryl group, an alkoxy group, or -NRR, wherein Rand Rare independently H, an alkyl group or an aryl group; R<3 >is (CH2)n where n is and integer in the range of 0 to 5, -CH2CH(CH3)-, -CH=CH-, -CH=C(CH3)-, or -C=C-; R<4 >is (CH2)p where p is an integer in the range of 4 to 12, -(CHR)y1(CHR)y2(CHR)y3(CHR)y4(CHR)y5C(R)=C(R)C(R)=C(R)-, -(CHR)y1(CHR)y2(CHR)y3(CHR)y4(CHR)y5CH(R)CH(R)C(R)=C(R)-, -(CHR)y1(CHR