| 摘要 |
<p>The invention rovides 4-amino-4-oxobutanoyl peptide compounds of FormulaI (I) and the pharmaceutically salts and hydrates thereof. The variables R1-R9,R16, R18 R19, n, M,, n, M,, and Z are defined herein. Certain compounds of FormulaI are useful as antiviral agents. Certain 4-amino-4-oxobutanoyl peptide compoundsdisclosed herein are potent and/ or selective inhibitors of viral replication,particularly Hepatitis C virus replication. The invention also provides pharmaceuticalcompositions containing one or more 4-amino-4-oxobutanoyl peptide compoundsand one or more pharmaceutically acceptable carriers. Such pharmaceuticalcompositions may contain 4-amino-4-oxobutanoyl peptide compound as the onlyactive agent or may contain a combination of 4-amino-4-oxobutanoyl peptidecontaining peptides compound and one or more other pharmaceutically activeagents. The invention also provides methods for treating viral infections,including Hepatitis C infections, in mammals.</p> |
