| 发明名称 | Feedback-resistant alpha-isopropylmalate synthases | ||
| 摘要 | The invention relates to an isolated nucleotide sequence encoding an amino acid sequence that is at least ≧90%, ≧92%, ≧94%, ≧96%, ≧97%, ≧98%, ≧99% or 100%, preferably ≧97%, particularly preferably ≧98%, very particularly preferably ≧99%, and extremely preferably 0%, identical to the amino acid sequence of SEQ ID NO:2, wherein SEQ ID NO:2, at position 553, or at a corresponding position of the amino acid sequence, has a proteinogenic amino acid other than L-tyrosine, to a microorganism comprising the nucleotide sequence and also to a process for producing fine chemicals using this microorganism. | ||
| 申请公布号 | US9347048(B2) | 申请公布日期 | 2016.05.24 |
| 申请号 | US201314385876 | 申请日期 | 2013.04.12 |
| 申请人 | Evonik Technochemie GmbH | 发明人 | Gerstmeir Robert;Wiegrabe Iris |
| 分类号 | C12N9/10;C12N1/20;C12N15/74;C12N15/77;C12P7/40;C12P13/06;C12P7/62 | 主分类号 | C12N9/10 |
| 代理机构 | Reed Smith LLP | 代理人 | Reed Smith LLP ;Evain Eric J.;Cox Ryan P. |
| 主权项 | 1. An isolated polynucleotide encoding an α-isopropylmalate synthase comprising an amino acid sequence that is at least 90% identical to the amino acid sequence of SEQ ID NO:2, wherein the amino acid sequence has a proteinogenic amino acid other than L-tyrosine at position 553 of SEQ ID NO:2 or at a corresponding position of the amino acid sequence. | ||
| 地址 | Dossenheim DE | ||