ErbB3 binding antibody

摘要

The present invention relates to an antibody, particularly a monoclonal antibody, which binds to the ErbB3 receptor, compositions comprising such an antibody as well as methods using such an antibody.

主权项

1. An antibody or fragment thereof which binds to the ErbB3 receptor and which comprises:
(a) a heavy chain amino acid sequence encoded by SEQ ID NO: 1 or at least the variable domain thereof or an amino acid sequence having a sequence identity of at least 95% thereto, wherein the heavy chain amino acid sequence comprises complementarity determining regions CDR1, CDR2, and CDR3, wherein CDR1 comprises the amino acid residues 50-54 from SEQ ID NO:3, CDR2 comprises the amino acid residues 69-85 from SEQ ID NO:3, and CDR3 comprises the amino acid residues 118-130 from SEQ ID NO:3 and (b) a light chain amino acid sequence encoded by SEQ ID NO: 2 or at least the variable domain thereof or an amino acid sequence having a sequence identity of at least 95% thereto, wherein the light chain amino acid sequence comprises complementarity determining regions CDR1, CDR2, and CDR3, wherein CDR1 comprises the amino acid residues 46-60 from SEQ ID NO:13, CDR2 comprises the amino acid residues 76-82 from SEQ ID NO:13 and CDR3 comprises the amino acid residues 115-123 from SEQ ID NO:13.