| 主权项 |
1. A compound of formula I:wherein:
Ring A is a 5-7 membered monocyclic or an 8-12 membered bicyclic, saturated, partially unsaturated, or aromatic, carbocyclic or heterocyclic ring system that is optionally substituted with one or more groups independently selected from hydroxy, halo, nitro, cyano, trifluoromethoxy, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, or (C3-C6)cycloalkyl, wherein the (C3-C6)cycloalkyl and (C1-C6)alkyl are each optionally substituted with one or more OH, SH, halo, or N(Ra)2; R5 is H, hydroxy, mercapto (—SH), halo, N(Ra)2, or (C1-C6)alkyl, wherein the (C1-C6)alkyl is optionally substituted with one or more hydroxy, mercapto, halo, or N(Ra)2; or R5 is absent when it is not required to fill the valence requirements of the ring A atom to which it is attached; either the bond represented by ---- is a double bond and R6 is H; or the bond represented by ---- is a single bond and R6 is hydroxy, H or N(Rb)2; R7 is H, (C3-C6)cycloalkyl, or (C1-C6)alkyl; R8 is —C(═O)Rc, —C(═O)ORc, —S(═O)Rc, —S(═O)2Rc, —C(═O)NRdRe; R9 is H, halo, (C3-C6)cycloalkyl, or (C1-C6)alkyl, wherein the (C3-C6)cycloalkyl and (C1-C6)alkyl are each optionally substituted with one or more OH, SH, halo, or N(Ra)2; R10 is H, halo, (C3-C6)cycloalkyl, or (C1-C6)alkyl, wherein the (C3-C6)cycloalkyl and (C1-C6)alkyl are each optionally substituted with one or more OH, SH, halo, or N(Ra)2; X is —C(═O)—O—, —O—C(═O)—, —C(═O)—NRa—, —NRaC(═O)—, —O—C(═O)—NRa—, —NRa—C(═O)—O—, —O—C(═O)—O—, or —NRa—C(═O)—NRa—; each Ra is independently H or (C1-C6)alkyl; each Rb is independently H or (C1-C6)alkyl; Rc is H, (C3-C6)cycloalkyl, or (C1-C6)alkyl; Rd is H, (C3-C6)cycloalkyl, or (C1-C6)alkyl; and Re is H, (C3-C6)cycloalkyl, or (C1-C6)alkyl; or a salt thereof. |
