TOPICAL COMPOSITION COMPRISING A FILM-FORMING POLYMER FOR DELIVERING AN ACTIVE INGREDIENT TO SKIN

摘要

A film-forming pharmaceutical composition for dermal application comprises at least one therapeutically active ingredient dissolved in a volatile solvent, the composition further comprising a film-forming polymer, a plasticizer and an oily release-enhancing agent. The composition is capable of forming, after application on skin and evaporation of the solvent, a continuous phase comprising the film-forming polymer and the plasticizer and a dispersed phase comprising droplets of the oily release-enhancing agent.

主权项

1. A film-forming pharmaceutical composition for dermal application, the composition comprising at least one therapeutically active ingredient dissolved in a pharmaceutically acceptable volatile solvent which is present in an amount of 50-99.5% w/w of the composition, the composition further comprising a film-forming polymer in an amount of 0.1-50% w/w, a plasticizer in an amount of 0.1-10% w/w, and medium chain triglycerides as an oily release-enhancing agent in an amount of 0.1-15% w/w;
the composition being capable of forming, after application on skin and evaporation of the solvent, a continuous phase comprising the film-forming polymer and the plasticizer and a dispersed phase comprising droplets of medium chain triglycerides.