Protein kinase inhibitors

摘要

A compound of formula (I), wherein R3, R4, G, B, M, and Z are as defined in the claims, and pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as FGFR inhibitors and are useful in the treatment of a condition, where FGFR kinase inhibition is desired, such as cancer.

主权项

1. A compound of formula (I) wherein Z is CH or N; G is a group of formula wherein ring A is a phenyl ring or a 5-12 membered heterocyclic ring, and R1 is H, C1-7 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-7 alkyl, C1-7 alkoxy, C1-7 alkyl carbonyl, amino, hydroxy, hydroxy C1-7 alkyl, C1-7 alkylamino C1-7 alkyl, phenyl C1-7 alkoxy, —NHC(O)—R21, —R12—C(O)—R13, —SO2—R14 or -E-R6, and R2 is H, halogen, C1-7 alkyl or oxo; ring B is a 5-12 membered carbocyclic or heterocyclic ring; R3 is H, halogen, C1-7 alkyl, C1-7 alkoxy, cyano or an optionally substituted 5-6 membered heterocyclic ring; R4 is H, halogen, C1-7 alkyl or oxo; M is —NHR5; R5 is H, —C(O)R7, —SO2R8, —C(O)-D-R9 or an optionally substituted 5-6 membered heterocyclic ring; R6 is an optionally substituted 5-6 membered heterocyclic ring; R7 is C1-7 alkyl, C2-7 alkenyl, C3-7 cycloalkyl, C1-7 alkoxy, C1-7 alkoxy C1-7 alkyl, carboxy C1-7 alkyl, C1-7 alkoxy carbonyl C1-7 alkyl, C1-7 alkylamino C1-7 alkyl, —NH—R10 or —NH—X1—R11; R8 is C1-7 alkyl, C2-7 alkenyl, C3-7 cycloalkyl, hydroxy C1-7 alkyl, —NR18R19, —NH—X2—R20, phenyl or an optionally substituted 5-6 membered heterocyclic ring; R9 is phenyl or an optionally substituted 5-6 membered heterocyclic ring; R10 is C1-7 alkyl or C3-7 cycloalkyl; R11 is phenyl or an optionally substituted 5-6 membered heterocyclic ring; R12 and R21 are C1-7 alkyl; R13 is C1-7 alkoxy, amino or hydroxy; R14 is C1-7 alkyl or C3-7 cycloalkyl; R18 and R19 are, independently, H, C1-7 alkyl or C3-7 cycloalkyl; R20 is phenyl or an optionally substituted 5-6 membered heterocyclic ring; E is a bond or a C1-7 alkyl; D is a bond or a C1-7 alkyl; X1 and X2 are, independently, a bond or C1-7 alkyl; or a pharmaceutically acceptable salt thereof.