Tricyclic compounds, compositions comprising them and uses thereof

摘要

Tricyclic compounds, compositions and uses thereof in the treatment of at least one disease, disorder or condition such as for example obesity, overweight, abnormal fat-distribution and any conditions or disease associated therewith.

主权项

1. A compound of the general formula (I): wherein: each of R1-R8 is independently selected from the group consisting of H, OH, SH, halogen, nitro, amino, nitrilo, nitroso, acetyl, acetamido, acylamido, alkylamino, straight or branched C1-C5 alkyl, straight or branched C1-C5 alkenyl, straight or branched C1-C5 alkynyl, amine, straight or branched C1-C5 alkoxy, straight or branched C1-C5 carboxyl, straight or branched C1-C5 ester, straight or branched C1-C5 thioxy, straight or branched C1-C5 sulfinyl and straight or branched C1-C5 thionyl; R9 is selected from the group consisting of straight or branched C1-C9 alkyl, straight or branched C1-C9 alkenyl, straight or branched C1-C9 alkynyl, piperazinyl, pyridinyl, piperidinyl, morpholinyl and thiomorpholinyl each being substituted with at least one quarternary amino group; at least one of R1-R4 is a halogen or nitro, and at least one of R5-R8 is a halogen or nitro; or at least one of R1-R4 or at least one of R5-R8 is OH; X is selected from the group consisting of CH, N and P; andY is null.