| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a simple method for converting a dihydroisoxazole derivative into a γ-hydroxyamino acid derivative important as various synthetic intermediates and further a method for producing monatins expectable as a sweetener or its ingredient. <P>SOLUTION: The method for converting the dihydroisoxazole derivative into the γ-hydroxyamino acid derivative is carried out by a catalytic hydrogenation reaction. In particular, 5-indolylmethyl-4,5-dihydroisoxazole-3,5-dicarboxylic acid can be subjected to the catalytic hydrogenation reaction to afford the high-purity monatins. <P>COPYRIGHT: (C)2004,JPO |
