发明名称 POLYMORPHOLIC FORM II OF CEPHAZOLIN SODIUM AND METHOD FOR ITS PREPARATION
摘要 The polymorphous form is used as an application in medicine. It exhibits an improved biological selectivity. It has the following absorption bands and areas in the IR spectra: 1250, 2245, 700-400, 900-700 and 3000-3600 cm<-1> and X-ray diffraction peaks at 3, 4, 8, 9, 13 degrees (θdegree) in angular frequencies between 2 and 25 degrees (θdegree), white powder with solubility in water 1:4, acidity (pH value) 4.54, specific optical rotation -15.6 degrees, water content 3.9 % and quantitative content 93.3 %. The new polymorphous form is obtained by suspending lyophilic cephazoline sodium in anhydrous acetonitrile, evaporating the solvent at room temperature and vacuum-drying the crystals so obtained over calcium chloride in a desiccator at a pressure of 0.7 kPa for 24-48 hours.
申请公布号 BG48976(A1) 申请公布日期 1991.07.15
申请号 BG19890089547 申请日期 1989.08.15
申请人 MEDITSINSKA AKADEMIJA 发明人 KALINKOVA, GALINA N.;GAGAUZOV, JORDAN N.;OVCHAROVA, GALINA D.
分类号 C07D501/36;(IPC1-7):C07D501/36 主分类号 C07D501/36
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