| 发明名称 |
STABLE PHARMACEUTICAL COMPOSITION OF BDNF |
| 摘要 |
A stable pharmaceutical composition of brain derived neurotrophic factor (BDNF) in the form of an aqueous solution or lyophilized one being suitable for a long-term storage, which contains a surfactant, especially nonionic surfactant (e.g., Tween 80) of 0.001 to 10 %, whereby the polymerization and the denaturation of BDNF are inhibited, and the biological activities of BDNF are maintained for a long time. Said lyophilized composition can be made more stable by addition of a sugar alcohol (e.g., mannitol) and/or an amino acid (e.g., glycine).
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| 申请公布号 |
WO9745135(A1) |
申请公布日期 |
1997.12.04 |
| 申请号 |
WO1997JP01746 |
申请日期 |
1997.05.26 |
| 申请人 |
REGENERON PHARMACEUTICALS, INC.;SUMITOMO PHARMACEUTICALS COMPANY, LIMITED;TANAKA, KATSUMI;KUMANO, MASASHI |
发明人 |
TANAKA, KATSUMI;KUMANO, MASASHI |
| 分类号 |
A61K9/08;A61K9/00;A61K9/14;A61K9/19;A61K38/00;A61K38/18;A61K47/10;A61K47/14;A61K47/18;A61K47/26;A61P3/04;A61P25/00;A61P25/04;A61P25/24;A61P25/26;A61P25/28;A61P27/02;(IPC1-7):A61K38/18 |
主分类号 |
A61K9/08 |
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