LOW MOLECULAR WEIGHT BICYCLIC THROMBIN INHIBITORS

摘要

This invention relates to discovery of competing heterocyclical ferment thrombin inhibitors, production of the same and it's pharmaceutical compositions. The invention also is related to use of the compounds and compositions as anticoagulants in vitro and use for treatment and disease prevention purposes in vivo as agents, intended for such thrombose disorders as vein thrombosis, thrombosis of lung artery by embolus and arterial thrombosis, arising in such cases of acute ischemia as myocardial infarct or cerebral infarct. In addition these compounds and compositions may be used for coagulopathy, related to operations of coronary shunting and remaining complications after transluminal angioplasty, for treatment and prophylaxis.