| 发明名称 |
ENDOTHELIN INTERMEDIATES BY ASYMMETRIC CONJUGATE ADDITION REACTION USING A CHIRAL ADDITIVE |
| 摘要 |
<p>This invention relates to a process for the preparation of a key intermediate in the synthesis of an endothelin antagonist, having formula (I) by using a chiral additive to effect an asymmetric conjugate addition.</p> |
| 申请公布号 |
EP0973742(A1) |
申请公布日期 |
2000.01.26 |
| 申请号 |
EP19980902416 |
申请日期 |
1998.01.09 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
TILLYER, RICHARD, D.;XU, FENG;TSCHAEN, DAVID, M. |
| 分类号 |
C07B37/02;C07B53/00;C07D213/30;C07D213/48;C07D213/55;C07D213/56;C07D213/85;C07D263/06;C07D263/52;(IPC1-7):C07D213/30;A61K31/44 |
主分类号 |
C07B37/02 |
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