| 摘要 |
The compound of formula I for the prevention of inflammation related cardiovascular disorders, providing the use of the compound of formula I is not in combination with a 5-lipoxygenase inhibitor, a leukotriene-A-hydrolase inhibitor or a leukotriene-B4-receptor antagonist. In the compound of formula I: A is selected from partially unsaturated or unsaturated heterocyclyl and partially unsaturated or unsaturated carbocyclic rings; R1 is selected from heterocyclyl, cycloalkyl, cycloalkenyl and aryl and is optionally substituted; R2 is a methyl or amino; R3 is a radical selected from hydrido, halo, alkyl, alkenyl, alkynyl, oxo, cyano, carboxyl, cyanoalkyl, heterocyclyloxy, alkyloxy, alkylthio, alkylcarbonyl, cycloalkyl, aryl, haloalkyl, heterocyclyl, cycloalkenyl, aralkyl, heterocyclylalkyl, acyl, alkylthioalkyl, hydroxyalkyl, alkoxycarbonyl, arylcarbonyl, aralkylcarbonyl, aralkenyl, alkoxyalkyl, arylthioalkyl, aryloxyalkyl, aralkylthioalkyl, aralkoxyalkyl, alkoxyaralkoxyalkyl, alkoxycarbonylalkyl, aminocarbonyl, aminocarbonylalkyl, alkylaminocarbonyl, N-arylaminocarbonyl, N-alkyl-N-arylaminocarbonyl, alkylaminocarbonylalkyl, carboxyalkyl, N-arylamino, N-aralkylamino, N-alkyl-N-aralkylamino, N-alkyl-N-arylamino, aminoalkyl, N-arylaminoalkyl, N-aralkylaminoalkyl, N-alkyl-N-aralkylaminoalkyl, N-alkyl-N-arylaminoalkyl, aryloxy, aralkoxy, arylthio, aralkylthio, alkylsulfinyl, alkylsulfonyl, aminosulfonyl, alkylaminosulfonyl, N-arylaminosulfonyl, arylsulfonyl, N-alkyl-N-arylaminosulfonyl. Providing that if A is imidazole, the sulfonylphenyl group is on the nitrogen atom that is the third ring atom, if A is pyrazole the sulfonylphenyl group is not substituted on a pyrazole ring nitrogen atom or the pyrazole ring carbon atom that is the fifth ring atom, if A is oxazole the sulfonylphenyl group is not substituted on the oxazole ring carbon atom that is the fifth ring atom, if A is isoxazole the sulfonylphenyl group is not substituted on the isoxazale ring carbon atom that is the third or fourth ring atom, if A is thiazole the sulfonylphenyl group is not substituted on the thiazole ring carbon that is the fourth or fifth ring atom.
|
