发明名称 |
Perlecan transgenic animals and methods of identifying compounds for the treatment of amyloidoses |
摘要 |
The invention provides a transgenic non-human animal expressing a perlecan encoding transgene. Also provided is a double-transgenic non-human animal expressing a perlecan and an amyloid encoding transgene. A method of screening for a compound which alters the rate or extent of amyloid deposition is additionally provided. The method consists of: (a) constructing a perlecan transgenic animal; (b) administering an effective amount of a test compound to said perlecan transgenic animal; and (c) determining whether said test compound alters the extent or rate of amyloid deposition. Finally, the invention provides a method of screening for a compound which alters the rate or extent of amyloid deposition. The method consists of: (a) constructing a perlecan/amyloid double-transgenic animal; (b) administering an effective amount of a test compound to said perlecan/amyloid double-transgenic animal; and (c) determining whether said test compound alters the extent o rate of amyloid deposition.
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申请公布号 |
US2007089175(A1) |
申请公布日期 |
2007.04.19 |
申请号 |
US20060481568 |
申请日期 |
2006.07.05 |
申请人 |
SNOW ALAN D;FUKUCHI KEN-ICHIRO;HASSELL JOHN |
发明人 |
SNOW ALAN D.;FUKUCHI KEN-ICHIRO;HASSELL JOHN |
分类号 |
A01K67/027;C12N15/09;A61K49/00;C07K14/47;C12N5/10;C12N15/85 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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