TREATMENT OF TUMORS WITH RAR ALPHA SELECTIVE RETINOID COMPOUNDS IN COMBINATION WITH OTHER ANTI-TUMOR AGENTS

摘要

Compounds which are specific or selective agonists of RAR.alpha. receptors i n preference over RAR.beta. and RAR.gamma. recep-tors, and particularly compounds of the formula (I) where R is a H, lower alkyl of 1 to 6 carbons, or a pharmaceutically acceptable salt, are useful for treating a malignant disease or condition in a mammal. In treatment of solid tumors the compound exhibit syn-ergistic antiproliferative effect with human recombinant interferon.