发明名称 |
peptídeo ou derivado de peptídeo, composição farmacêutica, uso de um peptídeo ou derivado de peptídeo, métodos para tratar um paciente tendo uma deficiencia e para preparar o peptídeo ou derivado de peptídeo. |
摘要 |
The invention provides a method of making a peptide comprising the amino acid sequence WDLYFEIVW (SEQ ID NO: 322) or a variant thereof, the method comprising (a) coupling the C-terminal amino acid of the peptide to a cleavable linking moiety bonded to a solid phase support material, wherein the alpha-amino group of the C-terminal amino acid that is to be coupled bears an Fmoc protecting group; (b) removing the Fmoc protecting group from the C-terminal amino acid that is coupled to the linking moiety; (c) successively coupling Fmoc-protected amino acids to the C-terminal amino acid, with attendant cleavage of the Fmoc protecting group prior to each successive amino acid addition, thereby producing an amino acid sequence bearing side chain protecting groups; and (d) removing the side chain protecting groups and cleaving the peptide from the solid phase support material. |
申请公布号 |
BRPI0911203(A2) |
申请公布日期 |
2016.07.05 |
申请号 |
BR2009PI11203 |
申请日期 |
2009.04.16 |
申请人 |
BAXTER HEALHCARE, S.A.;BAXTER INTERNATIONAL INC |
发明人 |
FRIEDRICH SCHEIFLINGER;MICHAEL DOCKAL |
分类号 |
C07K7/06;C07K7/08 |
主分类号 |
C07K7/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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