发明名称 |
Peptide agents for cancer therapy |
摘要 |
There is provided peptides for inhibiting growth of cancer cells, the peptides comprising the amino acid sequence RxKxKxxxxR wherein K and R are respectively lysine and arginine amino acid residues, each x is independently an amino acid, and 5 wherein the peptide has 50% or less amino acid sequence identity with the amino acid sequence RSKAKNPLYR (SEQ ID. No. 2). Each x amino acid may independently be an amino acid residue selected from the group consisting of alanine (A), valine (V), leucine (L), isoleucine (I), threonine (T) and serine (S) amino acid residues. There is also provided chimeric proteins incorporating a peptide of the amino acid sequence 10 RxKxKxxxxR, nucleic acids encoding for the peptide, expression vectors including a nucleic acid encoding the peptide for expression of the peptide, and methods for use of the peptide for inhibiting growth of cancer cells. |
申请公布号 |
US9403877(B2) |
申请公布日期 |
2016.08.02 |
申请号 |
US201314374245 |
申请日期 |
2013.01.24 |
申请人 |
INTER-K PTY LIMITED |
发明人 |
Agrez Michael Valentine |
分类号 |
C07K14/01;C07K14/00;C07K14/705;A61K38/00;C07K7/06;C07K7/08;A61K38/08;A61K38/10;A61K38/16 |
主分类号 |
C07K14/01 |
代理机构 |
Flener IP Law, LLC |
代理人 |
Flener IP Law, LLC ;Flener Zareefa B. |
主权项 |
1. An isolated or purified peptide for inhibiting growth of cancer cells, the peptide comprising an amino acid sequence RxKxKxxxxR (SEQ ID No. 5) wherein K and R are respectively lysine and arginine amino acid residues, each x is independently an amino acid selected from the group consisting of alanine (A), valine (V), and serine (S), and the peptide has a length of from 10 to 40 amino acids. |
地址 |
Newcastle, New South Wales AU |