| 摘要 |
The present invention provides a compound of Formula I or Formula II:;
enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically acceptable salt thereof, wherein constituent variables are provided herein. The compounds of Formula I and II are modulators of metalloproteases and are useful in treating diseases associated with metalloprotease activity such as arthritis, cancer, cardiovascular disorders, skin disorders, inflammation and allergic conditions. |
| 主权项 |
1. A method for treating a cancer selected from prostate cancer, non-small cell lung cancer, colon cancer, pancreatic cancer, and glioma in a mammal, comprising administering to said mammal a therapeutically effective amount of a compound of the following formula:or a pharmaceutically acceptable salt thereof, wherein:
X is CH2NRb; Y is (CH2)j; V is piperidin-1-yl, piperazin-1-yl, pyrrolidin-1-yl, pyridin-1-yl or 3,6-dihydropyridin-1-yl each substituted with 0-5 Re; V′ is phenyl substituted with 0-5 Re; Rb is H, C(O)O(CRb′Rc′)r-T, or C(O)(CRb′Rc′)r-T; Rb′ and Rc′ are both H; Re is H, C1-6 alkyl, OH, Cl, F, Br, I, CN, NO2, methoxy, ethoxy, n-propoxy, isopropoxy, phenoxy, benzyloxy, amino, (C1-4 alkyl)amino, (C2-8)dialkylamino, C(O)O(C1-4 alkyl), CONH2, CONH(C1-4 alkyl), CON(C1-4 alkyl)2, C1-6 haloalkyl, phenyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, benzyl, or phenethyl; T is H, C1-10 alkyl substituted with 0 to 5 Rb′; C2-10 alkenyl substituted with 0 to 5 Rb′, C2-10 alkynyl substituted with 0 to 5 Rb′, C3-13 carbocyclyl substituted with 0-3 Rb′, or heterocyclyl substituted with 0-5 Rb′; j is 1 or 2; and r is 0, 1 or 2. |
