Dual site catalyst for mild, selective nitrile reduction

摘要

A ruthenium bis(pyrazolyl)borate scaffold that enables cooperative reduction reactivity in which boron and ruthenium centers work in concert to effect selective nitrile reduction is provided. The pre-catalyst compound [κ3-(1-pz)2HB(N═CHCH3)]Ru(cymene)+ TfO− (pz=pyrazolyl) was synthesized using readily-available materials through a straightforward route, thus making it an appealing catalyst for a number of reactions.

主权项

1. A compound having formula I: wherein: R1 are each independently hydrogen, C1-8 alkyl, chlorine, bromine, fluorine, or OH; x is 0 to 3; R2 is C6-12 aryl, C5-12 heteroaryl or C1-8 alkyl; L1 are each independently ligands associated with M, each L1 are the same or different; and a is an integer from 1 to 6; and M is a transition metal.