| 摘要 |
Disclosed is a compound of formula (I):;;wherein L, R1-R5, A, B, M, and n are as defined in the specification, as well as a method of preparing the compound. Also disclosed are a method of blood-pool imaging in a mammal and a method of imaging a lymph node in a mammal, comprising use of the compound. |
| 主权项 |
1. A compound of formula (I): wherein L is a linker group selected from aryl, biaryl, heteroaryl, and biheteroaryl, wherein the aryl, biaryl, heteroaryl, or biheteroaryl is optionally substituted with one or more groups selected from alkyl, halo, hydroxy, and alkyloxy, wherein A is selected from a bond, C═O, and C1-C6 alkyl, wherein B is a chelating group selected from 1, 4, 7-triazacyclononane-N,N′,N″-triacetic acid, 1, 4, 7,10-tetrazacyclononane-N,N′,N″-triacetic acid, triethylenetetramine, diethylenetetramine pentaacetic acid, and hydrazinonicotinamide, wherein R1-R5 are independently selected from hydrogen, OH, NH2, and SO3H, wherein n is 0 or 1, and wherein M is selected from 18F-AlF, 60Cu, 61Cu, 62Cu, 64Cu, 67Cu, 68Ga, 86Y, 89Zr, 111In, 99mTc, 186Re, 188Re, Gd3+, and Mn2+. |
