| 摘要 |
Described is a stent device having a polymeric coating in which is incorporated a compound of formula (I) or an N- oxide, hydrate, solvate, prodrug, or salt thereof; where in the compound of formula (I): R1a is optionally substituted alkyl, hydroxy, acyloxy, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted oxaheterocyclyloxy, optionally substituted heterocyclylcarbonyloxy or halo; R1b is H, optionally substituted alkyl, hydroxy, acyloxy, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted oxaheterocyclyloxy, optionally substituted heterocyclylcarbonyloxy or halo; R1c is H, optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, hydroxy, acyloxy, optionally substituted alkoxy, optionally substituted cycloalkyloxy, optionally substituted heterocyclyoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocyclylcarbonyloxy, halo, cyano, R5R6N- or acylR5N-; R2 is optionally substituted phenyl or is optionally substituted benzyl; Za is N or CH; and Zb is NH or O. Also described is a pharmaceutical composition comprising a compound of formula (I). The compound of formula (I) is useful for preparing a stent device for treating a patient subject to restenosis, where the compound is incorporated into a polymeric material coated on the surface of the stent device. Also described are certain compounds of formula I.
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