| 摘要 |
The present invention provides a non-proteinaceous compound isolatable from the urine of patients suffering from steroid responsive nephrotic syndrome. The compound has the following characterising features; (i) a molecular weig ht less than 1 KDa; (ii) binds specifically to heparin and heparan sulphate but not other glycosaminoglycans; and (iii) inhibits LPS induced production of T NF- .alpha. and/or IL-1.alpha.. The present invention also provides a compound o f general formula: (I) in which l, m and n may be the same or different and integers of 0 to 10; and X is R-CO-O-, R-O-PO2-O-, R-O-SO2-O-, R-CO-NH-, R-C O- , R-O- or monosaccharide or oligosaccharide including amide substituted saccharides; in which R is a saturated, unsaturated, branched or cyclic carb on chain of up to 32 carbon atoms which optionally contains one or more hydroxy l groups, carbonyl groups, carboxylic acids groups, amino groups, phosphate groups or sulphate groups or combination thereof; and pharmaceutically acceptable salts and derivatives thereof.
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