Aryl sulfonic acids and derivatives as FSH antagonists

摘要

This invention provides compounds of formula I having the structure wherein Q is hydrogen or -SO2R1; X is a bond, O, S(O)n, -CH=CH-, -CH2CH2-, -C=C-, or -CH2S(O)nCH2-; R1 is OH, NH2, C1 to C6 alkoxy, C1 to C3 perfluoroalkoxy; R2 and R4 are each, independently, hydrogen, OR6, -S(O)mR6, -NHR6, -N(R6)2, or -CH2SO2CH3; R3 and R5 are each, independently, hydrogen, -NO2, -NH2, -SO2R9, or -CH2R9; R6 is hydrogen, C1 to C6 alkyl, C3 to C6 alkenyl, -CH2CH2Z, -CH2COR7, -CH2CH=CHCOR7 Y1 and Y3 are each, independently, N, or CH; Y2 and Y4 are each independently, O, S, or NR13; R7 is -OR8, -NHR8, -N(R8)2, or -NHCH2CH2OR8; Z is -OR8, -OCH2CH2OR8, -N(R8)2, or R8 is hydrogen, or C1 to C3 alkyl; R9 is C<highlight><