| 摘要 |
Methods and compositions for breast cancer treatment and prevention by inducing overexpression of adipose differentiation related protein (ADRP) in the cancer cells. Over expression of ADRP causes breast cancer cells to re-differentiate, whereby cancer cell proliferation and tumorigenesis is inhibited and cancer cells are induced to undergo apoptosis. Also disclosed are pharmaceutical compositions comprising polynucleotides encoding ADRP, ADRP polypeptides or analogs or mimetics thereof, and methods for screening for ADRP agonists. |
