发明名称 |
Medicinal Aerosol Formulation Products With Improved Chemical Stability |
摘要 |
The present invention relates to a medicinal aerosol formulation product with improved chemical stability. The product is a pressurized metered dose inhaler including an aerosol canister equipped with a metering valve provided with sealing rings and/or gaskets made of a vulcanisate of an elastomeric composition of a butyl rubber, a cross-linking agent for the butyl rubber, and an accelerator for the cross-linking agent. The accelerator includes a polysulphide compound derived from a substituted dithiocarbonic acid or derivative thereof. The pressurized metered dose inhaler contains in the aerosol canister a medicinal aerosol formulation containing a long acting beta2 agonist, a hydrofluorocarbon propellant, a co-solvent, and a mineral acid as a stabilizer for the active ingredient.
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申请公布号 |
US2007086953(A1) |
申请公布日期 |
2007.04.19 |
申请号 |
US20060558793 |
申请日期 |
2006.11.10 |
申请人 |
MEAKIN BRIAN;LEWIS DAVID;JOHNSON ROBERT;CHURCH TANYA |
发明人 |
MEAKIN BRIAN;LEWIS DAVID;JOHNSON ROBERT;CHURCH TANYA |
分类号 |
A61K9/12;A61K9/00;A61K31/16;A61K31/4704;B65D83/14 |
主分类号 |
A61K9/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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