BONE GRAFT CONTAINING OSTEOGENESIS ENHANCING PEPTIDES

摘要

The present invention relates to a physiologically active peptide for promoting osteogenesis, and a bone graft material for dental and orthopedic applications, which contains the peptide. More specifically, the bone graft material which contains a peptide having CEEEEEEEGG added to the N-terminus of a peptide derived from a bone morphogenetic protein and/or an extracellular matrix. The peptide for promoting bone tissue formation, which is contained in the bone graft material, can promote the growth, proliferation and differentiation of bone regeneration-associated cells to maximize tissue regeneration. Also, the peptide has a reduced risk of immune responses due to its low molecular weight when applied in vivo, and can be present in a stable form in vivo to show a long-lasting effect. Accordingly, the peptide makes it expedient to perform surgical operations for the regeneration of periodontal tissue, alveolar bone and other bone tissues, and is expected to show high therapeutic effects.